Microneedling Treatment and Aftercare

Published July 27th, 2026

Treatment Options & Patient Care Guide

PRP | BENEV SOOTHING MASK | REFINE PEPTIDE COMPLEX

• RENEW: Professional treatment options designed to support skin quality and visible rejuvenation.
• PREPARE: Clear pre-care instructions addressing sun exposure, skin products and treatment readiness.
• RECOVER: Practical guidance for makeup, downtime, sun protection and when to call the clinic.

EDUCATIONAL USE ONLY
This guide supports informed discussion and consistent aftercare. It does not replace an individualized medical assessment, informed consent, product labeling or your treating clinician's directions.

Microneedling Treatment Options

A concise clinical and patient-education overview

Microneedling uses controlled needle penetration to create microscopic skin injuries that initiate a wound-healing response. FDA-authorized devices have specific cleared indications, including improvement in the appearance of facial acne scars and facial wrinkles in adults 22 years and older. Treatment goals, device settings and adjunctive products must be individualized. [1]

Important regulatory note
The FDA has not cleared microneedling devices specifically to deliver platelet-rich plasma, cosmetics, peptide solutions, vitamin solutions, drugs or other topical products into the skin. Any adjunctive protocol must follow the device instructions, product labeling, clinician judgment and applicable scope-of-practice requirements. [1]

1. Microneedling with PRP: Collagen-induction therapy paired with autologous platelet-rich plasma prepared from the patient's own blood.
2. BENEV Exosome Soothing Gel Mask: A cooling, hydrating topical hydrogel mask used as a post-treatment comfort and barrier-support step.
3. Refine Peptide Complex (RCPR): A professional revitalizing complex containing hyaluronic acid, amino acids, antioxidants and biomimetic peptides.

WHAT PATIENTS SHOULD UNDERSTAND

• Results vary according to the concern treated, treatment depth, number of sessions, healing response and adherence to aftercare.
• Temporary redness, tightness, tenderness, dryness, pinpoint bleeding, swelling or peeling may occur after treatment. [1]
• The strongest published evidence for PRP-assisted microneedling is currently for atrophic acne-scar improvement; broader rejuvenation claims should remain conservative. [3]
• Product-based benefits for BENEV and Refine are primarily based on manufacturer-described cosmetic use and ingredient profiles. [4,5]

1. Microneedling with PRP

Professional description, clinical rationale and potential patient benefits

PROFESSIONAL MEDICAL DESCRIPTION

Microneedling with platelet-rich plasma (PRP) combines controlled collagen-induction therapy with an autologous blood product prepared from the patient's own blood. A blood sample is centrifuged to concentrate platelets and plasma. PRP may be applied or administered according to the clinician's protocol and applicable regulations.

Microneedling produces controlled microinjuries that activate a healing cascade and support remodeling of collagen and other extracellular-matrix components. Platelets contain signaling proteins associated with tissue repair. Because PRP is autologous, it avoids exposure to donor-derived biologic material; this does not eliminate procedural, blood-draw or infection risks.

POTENTIAL BENEFITS FOR APPROPRIATELY SELECTED PATIENTS

• Improves the appearance of atrophic acne scars.
• Supports gradual collagen and elastin remodeling.
• May improve uneven texture and overall skin smoothness.
• May soften the visible appearance of fine lines.
• May support a firmer, more radiant appearance over time.
• May provide greater acne-scar improvement and patient satisfaction than microneedling alone in published controlled studies. [3]
• Uses a preparation derived from the patient's own blood.

Evidence perspective
A 2022 meta-analysis of 14 controlled studies involving 472 patients found that microneedling plus PRP was associated with greater acne-scar improvement and higher satisfaction than microneedling without PRP. Severe erythema and edema were not statistically increased. Study protocols varied, and these findings do not guarantee an individual result. [3]

PATIENT-FACING DESCRIPTION

MICRONEEDLING WITH PRP
This treatment combines collagen-induction microneedling with platelet-rich plasma prepared from your own blood. It is designed to support the skin's natural renewal process and may improve the appearance of acne scars, fine lines, uneven texture, enlarged pores and dull skin. Results develop gradually as remodeling occurs, and a treatment series may be recommended.

ADDITIONAL CONSIDERATIONS

• A blood draw is required and may cause temporary bruising, tenderness or lightheadedness.
• Active infection, bleeding disorders, anticoagulant use, platelet disorders and other medical conditions may affect candidacy.
• Medical history, medications and procedural risks must be reviewed before treatment.

2. BENEV Exosome Soothing Gel Mask

Topical post-treatment cooling, hydration and comfort

PROFESSIONAL DESCRIPTION

The BENEV Exosome Soothing Gel Mask is a topical hydrogel mask intended to cool, soothe and moisturize skin after professional aesthetic procedures. BENEV describes the formula as containing human adipose stromal cell exosome ingredients, copper tripeptide-1, acetyl hexapeptide-8, glycerin, phospholipids, Centella asiatica, chamomile extract, beta-glucan and antioxidants. [4]

This is a topical cosmetic product and is not an injectable treatment. Its role in a microneedling visit is primarily post-procedure comfort, hydration and visible calming. Claims should not imply treatment of disease or guaranteed wound healing.

POTENTIAL PATIENT BENEFITS

• Provides an immediate cooling and comforting sensation.
• Intensively moisturizes temporarily dry or tight-feeling skin.
• Helps calm the visible appearance of post-treatment redness.
• Supports the skin's moisture barrier.
• May improve the appearance of temporary irritation and dryness.
• Leaves skin feeling softer, smoother and refreshed.
• Provides a relaxing finishing step after treatment.

Suggested professional use
BENEV instructs users to apply the mask to thoroughly cleansed, dry skin and leave it in place for approximately 10-20 minutes to allow the gel essence to absorb. Follow the current manufacturer instructions and clinic protocol. [4]

PATIENT-FACING DESCRIPTION

BENEV SOOTHING MASK
A cooling, deeply hydrating post-treatment mask used to calm and comfort the skin. It helps replenish moisture, reduce the visible appearance of temporary redness and support the skin barrier following microneedling.

USE AND SAFETY NOTES

• Review the complete ingredient list before use, especially in patients with a history of contact allergy or highly reactive skin.
• Discontinue and assess if marked burning, hives, progressive swelling or other signs of hypersensitivity occur.
• Do not reuse a single-use mask, and do not place it over visibly infected skin unless specifically directed by a qualified clinician.

3. Refine Peptide Complex (RCPR)

Professional revitalizing complex for hydration and visible skin quality

Product identification
This section refers to Toskani RCPR - Refine Complex Poli Revitalizing. Confirm the exact product, lot, labeling and intended professional-use protocol before using or publishing clinic claims.

PROFESSIONAL DESCRIPTION

Toskani describes RCPR as a professional revitalizing complex formulated with hyaluronic acid, glutathione, taurine, amino acids and biomimetic peptides, including SH-oligopeptide-1, SH-oligopeptide-2, SH-polypeptide-1, SH-polypeptide-2 and copper tripeptide. The manufacturer markets it for hydration, visible rejuvenation and smoother-looking texture. [5]

POTENTIAL PATIENT BENEFITS

• Provides intensive hydration and supports a plumper, more supple appearance.
• Improves the visible appearance of rough or uneven texture.
• May soften the appearance of early fine lines.
• May reduce the visible appearance of enlarged pores.
• Supports a brighter, refreshed-looking complexion.
• May improve the appearance of superficial post-acne marks.
• Provides skin-conditioning amino acids, antioxidants and peptide ingredients.

Claims perspective
These are manufacturer-described cosmetic benefits and ingredient-based rationale. They should not be presented as proof that the product heals disease, permanently remodels tissue or guarantees a particular clinical outcome. [5]

PATIENT-FACING DESCRIPTION

REFINE PEPTIDE COMPLEX
An advanced skin-revitalizing formulation containing hyaluronic acid, amino acids, antioxidants and biomimetic peptides. When incorporated into an appropriate professional treatment plan, it is designed to improve hydration, texture, radiance and the appearance of fine lines and enlarged pores.

PROFESSIONAL SAFETY CONSIDERATIONS

• Use only within the product's labeled route, instructions, storage conditions and applicable professional-use requirements.
• Confirm allergies, active dermatitis, infection and other contraindications before treatment.
• The FDA has not cleared microneedling devices for delivery of cosmetics or peptide solutions into the skin. [1]

Microneedling Pre-Care

Patient preparation checklist

SUN EXPOSURE

Avoid tanning beds and intentional sun exposure before treatment. Do not proceed on sunburned, recently tanned or actively irritated skin. Notify the clinic if a sunburn, significant tan, rash or infection develops before your appointment. FDA patient guidance advises against treatment when a patient is tan or planning significant sun exposure during the two weeks after the procedure. [1]

SKIN-CARE PREPARATION

• Use broad-spectrum sun protection and protective clothing in the weeks leading up to treatment.
• Unless your treating clinician gives different instructions, pause retinoids, retinol, tretinoin and strong exfoliating acids for approximately 3-5 days before treatment.
• Avoid scrubs, chemical peels, waxing and other irritating procedures near the treatment area.
• Arrive with clean skin and no makeup, sunscreen, oils or facial products.
• Do not pick, squeeze or aggressively exfoliate the treatment area.
• Maintain normal hydration and eat before the appointment when a blood draw for PRP is planned, unless instructed otherwise.

TELL YOUR CLINICIAN BEFORE TREATMENT IF YOU HAVE

• Active acne lesions, rash or skin infection
• Current cold sore or recurrent herpes simplex
• History of keloids or poor wound healing
• Bleeding or platelet disorder
• Use of anticoagulants or medicines affecting bleeding
• Immune suppression or uncontrolled diabetes
• Recent isotretinoin use
• Pregnancy or breastfeeding
• Allergy to stainless steel, topical anesthetics or proposed products
• Recent procedures, peels, laser treatment or significant sun exposure

Medication safety
Do not independently stop prescription anticoagulants, aspirin or other medically necessary medicines. Medication changes require direction from the prescribing clinician.

Microneedling Post-Care

Makeup, sun protection, skin care and activity

NO MAKEUP

Do not apply makeup for at least 24 hours. Wait 48 hours or longer if redness, pinpoint bleeding, weeping, significant irritation or sensitivity remains. Resume only when the skin surface is intact, using clean brushes, sponges and products. The American Academy of Dermatology advises waiting 24 hours before applying makeup. [2]

SUN PROTECTION

Avoid deliberate sun exposure and tanning for approximately two weeks. Minimize direct exposure during the first several days, use shade and a wide-brimmed hat, and resume a gentle broad-spectrum SPF 30 or higher when your clinician advises and the skin tolerates it. [1]

FIRST 24-48 HOURS

• Use only the gentle cleanser, moisturizer, mask or recovery products approved by your clinician.
• Avoid strenuous exercise, saunas, steam rooms, hot tubs and excessive heat for approximately 24-48 hours.
• Avoid swimming until the skin surface is closed and irritation has resolved.
• Keep hands, phones, pillowcases and towels clean around the treated area.
• Do not pick, scratch, scrub or peel flaking skin.

FOR APPROXIMATELY 3-7 DAYS OR UNTIL FULLY RECOVERED

• Avoid retinoids, glycolic acid, salicylic acid, exfoliating enzymes, benzoyl peroxide, fragranced products and alcohol-based products.
• Use lukewarm rather than hot water and avoid aggressive cleansing devices.
• Continue consistent sun protection to reduce the risk of post-inflammatory pigment changes.
• Follow individualized instructions if a deeper treatment, PRP, sensitive skin or another procedure was involved.

Expected Downtime & Recovery

Typical short-term responses after treatment

• First 24 hours:
  Common Experience: Redness or darkening, warmth, tightness, tenderness, mild swelling and possible pinpoint bleeding.
  Care Priority: No makeup. Gentle products only. Avoid heat, heavy exercise and touching.
• Days 2-3:
  Common Experience: Redness generally decreases; dryness, sensitivity or mild swelling may continue.
  Care Priority: Hydrate, protect from sun and continue gentle skin care.
• Days 3-7:
  Common Experience: Mild roughness, flaking or temporary darkening may occur.
  Care Priority: Do not pick or exfoliate. Resume actives only after recovery or clinician clearance.
• After one week:
  Common Experience: Most visible downtime has resolved for many patients; deeper treatments may take longer.
  Care Priority: Continue sun protection. Follow the treatment plan for future sessions.
• Weeks to months:
  Common Experience: Skin remodeling occurs gradually; visible improvement is not immediate.
  Care Priority: Attend follow-up and assess results over the clinician-recommended interval.

Most microneedling reactions improve within several days, although redness, peeling or sensitivity may last up to a week or longer after deeper treatment. FDA-listed risks include dryness, roughness, tightness, redness, itching, peeling, discomfort, burning, bruising, bleeding and crusting; less common risks include pigment changes, cold-sore reactivation and infection. [1]

Recovery varies
Skin type, treatment depth, anatomical area, number of passes, adjunctive products and individual healing response can change the downtime. Your clinician's personalized instructions take priority over general timelines.

When to Contact the Clinic

Recognizing symptoms that need professional assessment

CONTACT THE CLINIC PROMPTLY FOR

• Increasing pain, warmth, swelling or redness rather than steady improvement.
• Pus, yellow drainage, foul odor, spreading rash or fever.
• Blistering, hives, facial swelling or symptoms of an allergic reaction.
• A cold-sore outbreak or grouped painful blisters.
• Persistent bleeding, extensive bruising or severe swelling.
• New dark or light pigment changes that are pronounced or worsening.
• Any reaction that concerns you or differs from the aftercare plan.

Emergency symptoms
Seek urgent medical care for trouble breathing, swelling of the lips or tongue, fainting, chest pain, uncontrolled bleeding, rapidly progressive facial swelling or other severe symptoms.

CLINIC IMPLEMENTATION CHECKLIST

• Confirm device authorization, current labeling and single-use cartridge requirements.
• Document patient selection, consent, treatment settings, products, lot numbers and aftercare instructions.
• Use conservative, appearance-focused language for cosmetic product benefits.
• Maintain a clear complication-response and referral plan.
• Review this handout periodically as device labeling, product information and regulatory guidance change.

REFERENCES

1. U.S. Food and Drug Administration. Microneedling Devices.
2. American Academy of Dermatology. Microneedling can fade scars, uneven skin tone, and more.
3. Kang C, Lu D. Combined Effect of Microneedling and Platelet-Rich Plasma for the Treatment of Acne Scars: A Meta-Analysis. Front Med. 2022.
4. BENEV. Exosome Soothing Gel Mask - product information and directions.
5. Toskani Med. RCPR (Refine Complex Poli Revitalizing) - product information.

Prepared for Ellie's Aesthetics & Wellness. Educational material only. Review against current product labeling, device instructions, clinic policy and applicable New Mexico requirements before patient distribution.